肖智雄教授

中组部首批国家特聘专家，中国侨联特聘专家。四川省学术与技术带头人，四川省侨联特聘专家。曾任美国波士顿大学医学院生化系和医学系双聘教授、四川大学生命科学学院院长、科技部重大科学研究计划973项目首席科学家。现任四川大学生命科学学院学术院长、“生长代谢衰老研究中心”主任。基金委重点项目、重点国际合作项目负责人。美国癌症协会、美国生化和分子生物学协会和美国微生物协会会员。中国细胞生物学会信号转导分会理事，中国生物物理学会衰老生物学分会理事。主要从事肿瘤转移肿瘤耐药和细胞-器官衰老机理和干预研究，先后在Nature、PNAS、 Molecular Cell、Cancer Cell、Nature Communications、Oncogene、PLOS Biology、Aging Cell、JBC等国际一流杂志上发表论文100余 篇。获批国家发明专利4项，公开8项。现为Cell Death and Disease 编委；STTT (Signal Transduction and Targeted Therapy) 副主编。

研究方向

  • 肿瘤的生长、转移、代谢、耐药、免疫
  • 细胞与器官衰老
  • 转化医学

学术简历

  • 四川大学生物系生物化学专业理学学士学位和理学硕士学位
  • 教育部中美生化和分子生物学留美项目 （CUSBMBEA）选拔获选，留学美国
  • 获美国麻省大学（University of Massachusetts at Amherst）分子生物学博士
  • 哈佛大学医学院博士后
  • 美国波士顿大学医学院生化系和医学系助理教授、副教授、正教授

获奖情况

1991获美国Anna Fuller基金会的博后研究奖， 1995美国癌症学会资深博后研究学者奖。2006 年收入美国名人录。获多项美国NIH独立研究员研究项目资金， 美国国防部癌症研究专项基金，美国癌症协会项目研究基金以及美国麻州癌症研究专项基金，波士顿大学医学院WING TANG LEE 基金会研究基金。2016年获四川省天府友谊奖，2016年《科学中国人》杂志人封面人物。

学术成果

近年来代表作

  1. Juan Li, Yang Wang, Yue Luo, Yang Liu, Yong Yi, Jinsong Li, Yang Pan, Weiyuxin Li, Wanbang You, Qingyong Hu, Zhiqiang Zhao, Yujun Zhang, Yang Cao, Lingqiang Zhang, Junying Yuan, and Zhi-Xiong Jim Xiao. USP5-Beclin 1 axis overrides p53-dependent senescence and drives Kras-induced tumorigenicity. Nature Commun. 2022, 13:7799.
  2. Fengtian Li, Mengmeng Niu, Kewei Qin, Rongtian Guo, Yong Yi, Jing Xu, Luping Li, Siyi Xie, Mengyuan Fu, Nasi Wen, Wenting Liao and Zhi-Xiong Jim Xiao. Oncogene. 2023, 42:339-350.
  3. Yang Pan, Zhiqiang Zhao, Juan Li, Jinsong Li, Yue Luo, Weiyuxin Li, Wanbang You, Yujun Zhang, Zhonghan Li, Jian Yang, Zhi-Xiong Jim Xiao and Yang Wang. Nuclear Beclin 1 Destabilizes Retinoblastoma Protein to Promote Cell Cycle Progression and Colorectal Cancer Growth. Cancers. 2022, 14:4735.
  4. Yang Liu, Jianhong Gan, Rongqi Wang, Xiaocong Yang, Zhixiong Xiao and Yang Cao. DrugDevCovid19: An Atlas of Anti-COVID-19 Compounds Derived by Computer-Aided Drug Design. Molecules. 2022, 27:683.
  5. Yang Liu, Xiaocong Yang, Jianhong Gan, Shuang Chen, Zhi-Xiong Jim Xiao, Yang Cao. CB-Dock2: improved protein–ligand blind docking by integrating cavity detection, docking and homologous template fitting. Nucleic Acids Research. 2022, 50(W1):W159–W164.
  6. Mengmeng Niu; Jing Xu; Yang Liu; Yuhuang Li; Tao He; Liangping Ding; Yajun He; Yong Yi; Fengtian Li; Rongtian Guo; Ya Gao; Rui Li; Luping Li; Mengyuan Fu; Qingyong Hu; Yangkun Luo; Chunyan Zhang; Kewei Qin; Jianqiao Yi; Shuhan Yu; Jian Yang; Hu Chen; Liang Wang; Zhonghan Li; Biao Dong; Shiqian Qi; Liang Ouyang; Yujun Zhang; Yang Cao; Zhi-Xiong Jim Xiao, FBXL2 counteracts Grp94 to destabilize EGFR and inhibit EGFR-driven NSCLC growth. Nature Commun. 2021, 12(1): 5919.
  7. Mengmeng Niu; Yajun He; Jing Xu; Liangping Ding; Tao He; Yong Yi; Mengyuan Fu; Rongtian Guo; Fengtian Li; Hu Chen; Ye-Guang Chen; Zhi-Xiong Jim Xiao, Non-canonical TGF-β signaling leads to FBXO3-mediated degradation of ΔNp63α promoting breast cancer metastasis and poor clinical prognosis. PLOS Biology. 2021, 19(2):e3001113.
  8. Jing Xu; Fengtian Li; Ya Gao; Rongtian Guo; Liangping Ding; Mengyuan Fu; Yong Yi; Hu Chen; Zhi-Xiong Jim Xiao; Mengmeng Niu, E47 upregulates ΔNp63α to promote growth of squamous cell carcinoma. Cell Death and Disease. 2021, 12(4):381-381.
  9. Yong Yi; Deshi Chen; Juan Ao; Wenhua Zhang; Jianqiao Yi; Xiaokun Ren; Junjie Fei; Fengtian Li; Mengmeng Niu; Hu Chen; Yangkun Luo; Zhijun Luo; Zhi-Xiong Jim Xiao, Transcriptional suppression of AMPKα1 promotes breast cancer metastasis upon oncogene activation. Proc. Natl. Acad. Sci. U.S.A.. 2020, 117(14):8013-8021.
  10. Shengnan Sun; Hu Chen; Lijuan Sun; Miao Wang; Xianqiang Wu; Zhi-Xiong Jim Xiao, Hotspot mutant p53-R273H inhibits KLF6 expression to promote cell migration and tumor metastasis. Cell Death and Disease. 2020, 11:595.
  11. Yang Wang; Juan Li; Ya Gao; Yue Luo; Hong Luo; Liang Wang; Yong Yi; Zengqiang Yuan; Zhi-Xiong Jim Xiao, Hippo kinases regulate cell junctions to inhibit tumor metastasis in response to oxidative stress. Redox Biol. 2019, 26: 101233.
  12. Yi Yong; Zhang Wenhua; Yi Jianqiao; Xiao Zhi-Xiong*, Role of p53 Family Proteins in Metformin Anti-Cancer Activities (review). J Cancer. 2019, 10(11): 2434-2442.
  13. Tingjun Lei; Peixuan Zhang; Xudong Zhang; Xue Xiao; Jingli Zhang; Tong Qiu; Qian Dai; Yujun Zhang; Ling Min; Qian Li; Rutie Yin; Ping Ding; Ni Li; Yi Qu; Dezhi Mu; Jun Qin; Xiaofeng Zhu; Zhi-Xiong Xiao(*); Qintong Li(*), Cyclin K regulates prereplicative complex assembly to promote mammalian cell proliferation. Nature Commun. 2018, 9:1876.
  14. Hu, Linshan, Liang, Shan, Chen, Hu, Lv, Tao, Wu, Junfeng, Chen, Deshi, Wu, Min, Sun, Shengnan, Zhang, Haibo, You, Han, Ji, Hongbin, Zhang, Yujun, Bergholz, Johann, Xiao, Zhi-Xiong Jim, Delta Np63 alpha is a common inhibitory target in oncogenic PI3K/Ras/Her2-induced cell motility and tumor metastasis. Proc. Natl. Acad. Sci. U.S.A. 2017, 114(20): E3964-E3973.
  15. Yong Yi; Deshi Chen; Juan Ao; Shengnan Sun; Min Wu; Xiaorong Li; Johann Bergholz; Yujun Zhang; Zhi-Xiong Xiao, Metformin Promotes AMP-activated Protein Kinase-independent Suppression of ΔNp63α and Inhibits Cancer Cell Viability. J Biol Chem. 2017, 292(13):5253-5261.
  16. Lv, Tao, Wu, Xianqiang, Sun, Lijuan, Hu, Qingyong, Wan, Yang, Wang, Liang, Zhao Zhiqiang, Tu, Xiao, Xiao, Zhi-Xiong Jim, p53-R273H upregulates neuropilin-2 to promote cell mobility and tumor metastasis. Cell Death and Disease, 2017, 8(8):e2995-e2995.

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